Possible neurologic effects of aspartame, a widely used food additive.

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Possible neurologic effects of aspartame, a widely used food additive.

The artificial sweetener aspartame (L-aspartyl-L-phenylalanyl-methyl ester), is consumed, primarily in beverages, by a very large number of Americans, causing significant elevations in plasma and, probably, brain phenylalanine levels. Anecdotal reports suggest that some people suffer neurologic or behavioral reactions in association with aspartame consumption. Since phenylalanine can be neuroto...

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The use of naturally-occurring agents to regulate tumorigenesis is on the rise. Several herbal extracts, pure plant-derived active constituents, and food additives have been reported to possess potent anti-cancer properties and cancer-ameliorating effects. The wide-range anti-cancer effects of Nigella sativa, also known as black seed or black cumin, have been extensively studied using different...

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Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential

Magnesium stearate is widely used in the production of dietary supplement and pharmaceutical tablets, capsules and powders as well as many food products, including a variety of confectionery, spices and baking ingredients. Although considered to have a safe toxicity profile, there is no available information regarding its potential to induce genetic toxicity. To aid safety assessment efforts, m...

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Formaldehyde, aspartame, and migraines: a possible connection.

Aspartame is a widely used artificial sweetener that has been linked to pediatric and adolescent migraines. Upon ingestion, aspartame is broken, converted, and oxidized into formaldehyde in various tissues. We present the first case series of aspartame-associated migraines related to clinically relevant positive reactions to formaldehyde on patch testing.

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Quality Control of Widely Used Therapeutic Recombinant Proteins by a Novel Real-Time PCR Approac

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1987

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.877553